Modulation of the age at onset of Parkinson's disease by apolipoprotein E genotypes
Identifieur interne : 002012 ( Main/Exploration ); précédent : 002011; suivant : 002013Modulation of the age at onset of Parkinson's disease by apolipoprotein E genotypes
Auteurs : Zareparsi [États-Unis] ; Jeffrey Kaye [États-Unis] ; Richard Camicioli [États-Unis] ; Holly Grimslid [États-Unis] ; Barry Oken [États-Unis] ; Michael Litt [États-Unis] ; John Nutt [États-Unis] ; Thomas Bird [États-Unis] ; Gerard Schellenberg [États-Unis] ; Haydeh Payami [États-Unis]Source :
- Annals of Neurology [ 0364-5134 ] ; 1997-10.
Abstract
Parkinson's disease (PD) patients often develop dementia, and Alzheimer's disease (AD) patients frequently develop parkinsonian signs. The apolipoprotein E σ4 allele is associated with increased risk and earlier onset of AD. We studied 137 unrelated white PD patients. Those with σ4 had the earliest onset (52.7 · 9.8 years), σ3/σ3 patients had an intermediate onset (56.1 · 11.1 years), and those with σ2 had the latest onset (59.1 · 13.4 years). The age at onset distribution for σ4/σ – was significantly earlier than for σ3/σ3 and σ2/σ3. These preliminary results suggest that apolipoprotein E genotypes modulate the age at onset of PD.
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DOI: 10.1002/ana.410420417
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type="state">Oregon</region></placeName><wicri:cityArea>Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland</wicri:cityArea></affiliation></author><author><name sortKey="Nutt, John" sort="Nutt, John" uniqKey="Nutt J" first="John" last="Nutt">John Nutt</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oregon</region></placeName><wicri:cityArea>Department of Neurology, Oregon Health Sciences University, Portland</wicri:cityArea></affiliation></author><author><name sortKey="Bird, Thomas" sort="Bird, Thomas" uniqKey="Bird T" first="Thomas" last="Bird">Thomas Bird</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Neurology Section, University of Washington, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><country 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xml:lang="en">Parkinson's disease (PD) patients often develop dementia, and Alzheimer's disease (AD) patients frequently develop parkinsonian signs. The apolipoprotein E σ4 allele is associated with increased risk and earlier onset of AD. We studied 137 unrelated white PD patients. Those with σ4 had the earliest onset (52.7 · 9.8 years), σ3/σ3 patients had an intermediate onset (56.1 · 11.1 years), and those with σ2 had the latest onset (59.1 · 13.4 years). The age at onset distribution for σ4/σ – was significantly earlier than for σ3/σ3 and σ2/σ3. These preliminary results suggest that apolipoprotein E genotypes modulate the age at onset of PD.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Oregon</li><li>Washington (État)</li></region></list><tree><country name="États-Unis"><region name="Oregon"><name sortKey="Zareparsi" sort="Zareparsi" uniqKey="Zareparsi" last="Zareparsi">Zareparsi</name></region><name sortKey="Bird, Thomas" sort="Bird, Thomas" uniqKey="Bird T" first="Thomas" last="Bird">Thomas Bird</name><name sortKey="Bird, Thomas" sort="Bird, Thomas" uniqKey="Bird T" first="Thomas" last="Bird">Thomas Bird</name><name sortKey="Camicioli, Richard" sort="Camicioli, Richard" uniqKey="Camicioli R" first="Richard" last="Camicioli">Richard Camicioli</name><name sortKey="Grimslid, Holly" sort="Grimslid, Holly" uniqKey="Grimslid H" first="Holly" last="Grimslid">Holly Grimslid</name><name sortKey="Kaye, Jeffrey" sort="Kaye, Jeffrey" uniqKey="Kaye J" first="Jeffrey" last="Kaye">Jeffrey Kaye</name><name sortKey="Kaye, Jeffrey" sort="Kaye, Jeffrey" uniqKey="Kaye J" first="Jeffrey" last="Kaye">Jeffrey Kaye</name><name sortKey="Litt, Michael" sort="Litt, Michael" uniqKey="Litt M" first="Michael" last="Litt">Michael Litt</name><name sortKey="Litt, Michael" sort="Litt, Michael" uniqKey="Litt M" first="Michael" last="Litt">Michael Litt</name><name sortKey="Nutt, John" sort="Nutt, John" uniqKey="Nutt J" first="John" last="Nutt">John Nutt</name><name sortKey="Oken, Barry" sort="Oken, Barry" uniqKey="Oken B" first="Barry" last="Oken">Barry Oken</name><name sortKey="Payami, Haydeh" sort="Payami, Haydeh" uniqKey="Payami H" first="Haydeh" last="Payami">Haydeh Payami</name><name sortKey="Payami, Haydeh" sort="Payami, Haydeh" uniqKey="Payami H" first="Haydeh" last="Payami">Haydeh Payami</name><name sortKey="Schellenberg, Gerard" sort="Schellenberg, Gerard" uniqKey="Schellenberg G" first="Gerard" last="Schellenberg">Gerard Schellenberg</name><name sortKey="Schellenberg, Gerard" sort="Schellenberg, Gerard" uniqKey="Schellenberg G" first="Gerard" last="Schellenberg">Gerard Schellenberg</name><name sortKey="Schellenberg, Gerard" sort="Schellenberg, Gerard" uniqKey="Schellenberg G" first="Gerard" last="Schellenberg">Gerard Schellenberg</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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